What is Allulose? Is Allulose a Safe Sugar Substitute?

There’s A New Sugar In Town – Allulose

Move over stevia. Not so fast erythritol. There is a new rising star in the unending search for the best sugar substitute. It’s name is Allulose. So, what is allulose? Allulose is a non-GMO simple sugar that has only has 10% of the calories of regular sugar.

what is allulose

We recently got our ketokrate that provides samples of keto and paleo friendly snacks made by companies that are not the big wig sugar pumping conglomerates. Let’s face it, I live in the fattest, most unhealthy state in the world (literally) so I really have to reach out to find normal human foods so I stay in the best health possible! In our ketokrate was an amazing looking cookie by Know Better Foods, and the sugar amount was 28g! “What?! this can’t be appropriate for ketogenic dieters, there’s no way!” I said.

Then I saw it…Allulose! It hit me…Essentially, allulose has one tenth the calories and carbohydrates of table sugar.  Where 10g of sugar has 40 calories, and 10g of carbs–10g of allulose has 1 calorie and 1g of carbs.

Given that the Know Better cookies have 28g of allulose–this acts as 2.8g of carbohydrate in the body.

It’s ok if you’ve not heard of this new sugar yet. In fact, my wife’s first question after she at the cookie, was, “Hey! this has way too much sugar!..” I stopped her and said, “don’t worry, it’s allulose, and thats the way they have to report it!” Of course, her response was, “What’s allulose?!” And like her,  just about all the recipients of the ketokrate were in an uproar wondering “what is allulose,” and “how can this cookie” be considered keto?! Keep reading…

Allulose is found in nature, along with many other sugars, in small quantities in foods such as figs, raisins and maple syrup. It is just now starting to hit the market so depending on when you’re reading this, allulose may be brand new to you.

You might be interested to know that allulose is not a digestible sugar. This is NOT a problem!  Unlike some sugar alcohols that can cause some uncomfortable stomach issues, allulose simply filters out through the kidneys with no ill effects.

You can add it to anything and the taste is essentially like sugar. It’s just about like fructose. The ultimate test is making chocolate, and it passes the sugar test! Moreover,  allulose has a Glycemic Index of 0!

And the best new?  It doesn’t taste funny.  No aftertaste and no weird cooling effect.W

Where to Get Allulose

At this time, you can get the best deal HERE at Amazon!

Is Allulose the Ultimate Sugar Alternative?

It’s interesting that the FDA doesn’t really know what to do with it because it’s a sugar, so you can’t technically say that something with allulose is “sugar free.”

For my fellow nerds on the chemistry end,  think of it as allulose,  D-Psicose or an epimer of fructose.

Like I said above, it’s very similar to fructose except allulose has one “OH” that is flipped in the other direction.  That’s it.

A few more details.

  • ~70% as sweet as Sucrose
  • No aftertaste
  • No gastric upset
  • GI of 0

The end result is that our taste buds react to it the same way but in the same way some people don’t have the enzyme to digest lactose, humans don’t have the enzyme to digest allulose.

How do you use it?  Just like granulated sugar but you need to use a little more.  The literature says it is closer to 80% sweet as sucrose (table sugar) but I found in testing that it actually took more to taste similar.

what is allulose

How much to use? Simply start with multiplying it by 1.4 and adjust from there if needed. For example, 2tbs of sugar would be 2 x 1.4 = 2.8 so I’d use 3 tbs of allulose.

 

Is Allulose Safe? What Does Research Show?

Not to get too excited, but I think we’re about to see a huge shift in the sugar and diet industries (multi billion dollar industries). Research shows the anti-hyperlipidemic effect of D-allulose, combined with its anti-inflammatory actions on adipocytes, is beneficial for the prevention of both obesity and atherosclerosis and is accompanied by improvements in insulin resistance and impaired glucose tolerance. SEE ARTICLE HERE

Research thus far shows that allulose is not only safe but that it has the potential to revolutionize how we can handle and treat obesity. As Chung et al (3) states, “we can develop D-psicose (allulose) as a sugar substitute and food ingredient since it can prevent obesity in normal people, but also suppress adiposity as a sugar substitute or food ingredients with antiobesity effect in obese people. D-psicose can be unique functional sweetener because of its function of reducing visceral fat mass and weight gain.”

Allulose passes through the body without significant metabolism.

Allulose is absorbed by the small intestine and excreted in the urine without being significantly metabolized. A study in 14 healthy adults consuming allulose at 5 to 20 g reported urinary excretion of allulose at 66-79% and low microbial fermentability of allulose in the large intestine [1]. In another study, 8 healthy adults consumed 15 g unlabeled allulose with 776 nCi of 14C-allulose. Results showed that 86% of the radioactive dose was excreted in the urine, less than 3% excreted in the feces, and virtually no radioactivity was detected in expired air. Of the radioactivity in the urine, intact allulose was predominant (84%) with no other metabolites detected indicating that allulose is absorbed in the small intestine and excreted in the urine without undergoing significant metabolism [2].

Allulose produced a neglible amount of energy

The energy value of allulose is predicted to be 0.2 kcal/g, a negligible amount based on human studies. A study in healthy adults reported that allulose, absorbed in small intestine, was not metabolized into energy as neither carbohydrate energy expenditure (CEE) nor respiratory quotient (RQ) increased in three hours after ingestion of 0.35 g/kg body weight or 20 g allulose [1]. A 0.9 to 1.6 kJ/g energy yield (0.2-0.4 kcal/g) was predicted based on low breath hydrogen excretion (due to low colonic fermentation) following intake of 5-20g allulose in the same study [1]. Another study evaluating absorption, metabolism, and excretion showed no significant metabolism of allulose [2]. Thus, the caloric value of allulose is likely negligible.


References

[1] Iida T, Hayashi N, Yamada T, Yoshikawa Y, Miyazato S, Kishimoto Y, Okuma K, Tokuda M, Izumori K. Failure of d-psicose absorbed in the small intestine to metabolize into energy and its low large intestinal fermentability in humans. Metabolism 2010; 59:206-214.

[2] Williamson et al. A single dose microtracer study to determine the mass balance of orally administered, 14C-labeled sweetener in healthy adult men. FASEB J 2014; 28(1):LB450.

What Allulose Is Not

I feel like we’ve covered, “what is allulose,” so now we need to cover what allulose is not…Allulose is NOT an “artificial sweetener” with the questionable reputation, functionality and sensory profile of saccharin or aspartame. It has 10% the Calories of Traditional Sugar. It’s sugar, by another name.

The U.S. FDA grants Allulose Generally Recognized as Safe (GRAS) status and sanctions its use in moderate amounts by consumers of all ages.

There you have it.

References:

  1. https://www.ncbi.nlm.nih.gov/pubmed/26297965
  2. https://www.ncbi.nlm.nih.gov/pubmed/26012374
  3. https://www.ncbi.nlm.nih.gov/pubmed/22339545

29 thoughts on “What is Allulose? Is Allulose a Safe Sugar Substitute?”

  1. Very interesting read! I personally don’t use any sugar subs. I prefer natural alternatives as sweeteners like real sugar such as raw or organic but I know they still can cause obesity and other issues. However, still better for us than the fake sugars in moderation…for some of course. I’ll look more into this other sugar. I’m always reading and looking for new things to try and share with others. I’ve set a goal to try and get better fit and hopefully help others understand “diets” aren’t the answer! It’s definitely a lifestyle change and to eat real food! Thanks for sharing!

    1. Hey Tammy! You are right! And allulose is a real food…it’s not a sugar substitute technically or a sugar alcohol. It’s a sugar with no effect on blood sugar or insulin. There are no ill digestive effects either. Allulose is safely excreted by the kidneys, so you get the benefit of a sweetener (a real sugar) without all the negative effects. It’s a real game changer. Thanks for your comment!

      1. Hi Dr. Wade, my only concern is, since it is similar to fructose, does the liver metabolism Allulose in a similar way as fructose? Because my understanding is that fructose when metabolized by the liver is basically a poison and increase adipose development. Or as you said is it purely excreted by the kidneys and if so and problems with possible kidney harm?

        1. Hi Jeremy. Interesting thoughts…there have been no maleffects from allulose even with heavy dosages like they did with asparatame and saccharine. It’s a real sugar, and yes, your body simply tends to excrete via the kidneys without harm. It’s not an artificial substance and although similar to fructose, it is different enough to where it does not have the same effect in the liver.

      2. How can we be sure it is not made with GMO corn? I’ve heard that it is, from 3 folks now.

        Amy

        1. I am unaware that this particular brand is made from GMO corn. If you find evidence of this, please post it here!

  2. Very nice article! I’ve personally been dealing with this sugar for more than two years already and am planning to have my own start-up company for mass production of it. It’s certainly an encouragement to see a recent article like this.

  3. Do you know if any adverse effects on the GI system… since it’s not metabolized, but is absorbed, can it cause GI upset (gas, bloating, etc.)?

    1. None reported so far! It is a real sugar, not a substitute or a sugar alcohol, so the initial absorption is the same other than it is soon excreted by the kidneys. Hope this helps!

  4. You mentioned this sugar is dealt with through the kidney so would this be a bad idea to use if someone like had a kidney issue such as a nephritis? Mine are currently 40% efficient but stabilised

    1. I see no problem with this as there is not “extra” work on the kidneys. It’s a very natural process for your kidneys to excreted allulose just like it does other substances. Be sure to check with your Nephrologist to be sure!

  5. OOOOOhhhhh! I’m looking forward to trying this! I bake a lot and LOVE sweets… yet, I am a hard core LCHFer… so 🙂 🙂
    Thanks for the info! Off to read the studies!!!

    Mia

    1. In my opinion yes. It is naturally occurring yet chemically made. It can be argued. Depends on how “paleo” you want to be. This is not an artificial substance.

  6. I’d like to know how and WHAT (specifically) allulose is made from. What’s the process? Are there any other chemicals or solvents involved?
    Thank you!

    1. It is derived from fermented corn. Small amounts of the low-calorie sugar are also naturally found in figs, raisins, and maple syrup. It is considered natural. There are no harsh chemical extraction processes. It does not carry any constituents related to corn so those who have issues with corn or lectins are A OK to proceed with allulose.

    1. There is no known effect on cholesterol, but I must reference you to the publication “Eat Meat and Stop Jogging” by Mike Sheridan. It’s a provocative title obviously, but it has a ton of well cited studies on cholesterol that you really need to understand. People continue to die because of lack of understanding and they continue to implement practices that hurt them and not help, i.e. Cherio’s and Oatmeat along with other “whole grain” approaches. The only way I’ve ever helped bring harmful cholesterol and triglyceride levels into healthy ranges is to remove grains – period.

  7. Interesting research but one fatal flaw from my perspective. The number of study subjects is not statistically significant in either of the studies referenced. This causes me to question why they used less than 30 (minimum standard) and the validity of their claim. If they really believe this stuff is as good as they say, then they need to publish studies reflecting or supporting this belief. I think I will reserve my opinion until some statistically significant research is published. Thanks for you information.

    1. Not to my knowledge. It does have a different chemical structure than fructose, of course. To date, I’ve not had any reports of UTI. The only rare occurrence seems to be GI upset in some individuals. It was reported to me in another post that 1 in 8 people don’t have the enzyme to digest allulose hence the GI upset. I do not have confirmation of this or a source to validate it. Thank you for your question.

  8. Hi Dr Wade,
    You do have some of the most comprehensive and well-articulated videos and articles about Allulose on the web!
    I’m not connected with Jeremy (who commented above), but I have launched a business distributing Allulose in what we think is an innovative and useful way: As you know, Allulose is about 70% as sweet as sugar, so we have a blend of Allulose with a touch of Monk Fruit and Stevia, which brings it to 100%, 1:1 sugar product.
    We are also not connected with the brave pioneer of Allulose sales to the public, Keystone Pantry.
    So here’s the question: could we quote portions of your articles for use on our Facebook and website pages, and, well, not include the link to Keystone Pantries, our esteemed competitor? If there is a way that we could work with you on that, we’d be so grateful!

    Thanks,
    Martha Sandino
    Founder of NutriTactics, presenting Keto Genie Allulose

    1. Sounds like a good blend for the keto market. Have you had any feedback regarding those who do have digestive issues with allulose? It has to do with a portion of the population not having the necessary enzyme to break this substance down. I’ve had 2 clients so far that have pretty immediate reactions, but it is few and far between. Other than that, allulose continues to be a good sweetener without creating adverse blood sugar and insulin responses. Yes, I’m open to you quoting my article. Inbox me at drwadebaskin@gmail.com

  9. I have two grand-daughters with fructose mal-absorption. Any ingestion of fructose (stone fruits, honey, raisins, etc. or too much table sugar) causes severe abdominal pain. They may have maple syrup as it’s handled differently in the body. How would they most likely react to allulose?

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